Abstract: With the development of seismic exploration technology, S-wave exploration technology has provided a new research direction for oilfield development and reserve increases. Pure S-wave seismic data, if not affected by fluid, can effectively eliminate the influence of gas cloud and help to produce a real image of geological structures. Moreover, when the frequency bandwidth and dominant frequency of pure S-wave seismic data are similar to those of P-waves, the vertical resolution of S-wave seismic data is much higher than that of P-wave seismic data owing to the low propagation speed of the S-wave. In this study, the advantages of pure shear wave seismic data were first analyzed from three aspects: restoration of gas cloud imaging, improvement of fault recognition ability, and improvement of vertical resolution. Thereafter, the P-wave and pure S-wave joint interpretation technology was introduced in detail, including the basic principle of S-wave prestack AVO synchronous inversion and the key technology of P-wave and pure S-wave joint interpretation. Finally, the P-wave and pure S-wave seismic data in the Tuofeng Mountain area in the Sanhu Depression of the Qaidam Basin were introduced to reveal the effect. The results showed that the advantages of pure S-wave seismic data in the joint interpretation application in the gas cloud area are that it can accurately identify the distribution characteristics of faults in the gas cloud area and present a fine interpretation of geological structures in the gas cloud area. In sand reservoir description and gas bearing prediction, the vertical resolution and prediction accuracy of thin interbed reservoirs in the area were effectively improved using P-wave and S-wave prestack AVO synchronous inversion technology. It also resulted in good geological effects in the identification of lithological gas reservoirs. In conclusion, the results of the study demonstrate that the joint seismic exploration of P-wave and pure S-wave has an outstanding geological effect and broad application prospects.