Abstract: Time-lapse seismic exploration is advanced in reservoir management and monitoring,which plays an important role in the development of oil and gas field.Non-repeated time-lapse seismic acquisition doesn’t consider the requirement of time-lapse seismic monitoring;therefore,the two non-repeated datasets has obvious difference in time,energy,bandwidth and phase feature.So we introduced cross-equalization method,which can improve the consistency of two datasets effectively by two steps:firstly,best matching filter was obtained by computing correctors,then applying the filter to the monitoring data.To verify the validity of the method,we applied cross-equalization technology to simulate the response of time-lapse seismic data of water-drive reservoir under different water saturation with non-repeated time,amplitude,bandwidth and phase.Meanwhile,the testing data of zero-time repeated/non-repeated acquisition was used for analyzing the application effect.The result shows that the impact of inconsistency factors was eliminated effectively and ideal time-lapse responses were obtained.Moreover,we applied the cross-equalization method to process the real non-repeated datasets with thirteen years’ acquisition time interval,which weakened the unexpected differences of seismic responses and highlighted the time-lapse seismic response of reservoir fluid variation caused by long-term production.