Abstract: Outcrop of carbonate formation of different geological periods can be widely seen in central Guizhou province. There are some difficulties during data acquisition because of 1) the fluctuating surface, the steep dip angle of formations, and the complex lithology with big changes in horizon and vertical, resulting in bad shooting and receiving conditions, 2) the well-developed karst caves and fractures scattered in all directions, 3) the existing surface wave and refraction wave causing a strong secondary linear interference, 4) the big change in buried depth of target formation and the well developed faults, resulting in bad imaging effect, and 5) the strong absorption and attenuation making the S/N low. Aiming at these problems, the acquisition method suitable for this area was probed and the acquisition factors analyzed, including group interval, maximum offset, fold, shooting-well depth, shooting lithology, shooting explosive amount, and seismometer pattern layout. The acquisition method was ultimately determined as small group interval, long array, high fold, deep shooting depth, saturated shooting charges, and more strings of geophone array etc. The actual application shows that the acquisition method can enhance the S/N of seismic data, improve the imaging effect, and satisfy the exploration requirements in carbonate outcropped area.