Abstract: There exist some problems in subsalt seismic exploration of Caspian seashore basin, such as salt doom screening, interference wave development, weak energy of reflected wave, shortage of prior data and pseudo-structures caused by velocity anomaly, etc. Aiming at these problems, we have designed the processing workflow to effectively suppress the surface wave interference, regular interference, high energy interference, and other random noise interference. The treatment clue was from thick to thin. Firstly, the spectral analysis method was used to establish macroscopic velocity field. Then, the ray tomography method was used to enhance the accuracy of velocity analysis and to establish a more accurate velocity model. Finally, the finite difference pre-stack depth migration method in f-k domain was adopted to solve the imaging problem of subsalt and salt dome flank. The data processing result demonstrates that using the above treatment scheme can clearly image the subsalt and salt dome flank and effectively remove the structure artifacts caused by the velocity anomaly.